Clinical Trials

Featured Clinical Trials

• Commentary
• Landmark

• ADVANCE III
  Title:	Avoid Delivering Therapies for Nonsustained Arrhythmias in ICD Patients
  Year:	2013

  Clinical Trial:	Multicenter Automatic Defibrillator Implantation Trial–Reduce Inappropriate Therapy
  Journal Scan:	Effect of Long-Detection Interval vs Standard Detection Interval for Implantable Cardioverter-Defibrillators on Antitachycardia Pacing and Shock Delivery: The ADVANCE III Randomized Clinical Trial
  Cardiosource Video News:	ARISTOTLE, ADVANCE III and Fish Oil
  :	Cardiac Rhythm Management

• Risk and Prevention Study
  Title:	n-3 Fatty Acids in Patients With Multiple Cardiovascular Risk Factors
  Year:	2013

  Cardiosource Video News:	N-3 Fatty Acids for Prevention
  Cardiosource Video News:	ARISTOTLE, ADVANCE III and Fish Oil

• REVERSE
  Title:	REsynchronization reVErses Remodeling in Systolic left vEntricular dysfunction
  Year:	2008, 2013

  Summary Slide(s):	REVERSE Summary Slide (Update)
  Slide Set(s):	REVERSE
  Clinical Trial:	Multicenter Automatic Defibrillator Implantation Trial–Cardiac Resynchronization Therapy
  Clinical Image:	REVERSE Study Presentation Slides
  Journal Scan:	Long-Term Impact of Cardiac Resynchronization Therapy in Mild Heart Failure: 5-Year Results From the Resynchronization Reverses Remodeling in Systolic Left Ventricular Dysfunction (REVERSE) Study

• ARMYDA-8 RELOAD-ACS
  Title:	Antiplatelet therapy for Reduction of MYocardial Damage during Angioplasty
  Year:	2013

  Clinical Trial:	Antiplatelet Therapy for Reduction of Myocardial Damage During Angioplasty-4 RELOAD

• ATLAS ACS 2-TIMI 51
  Title:	Anti-Xa Therapy to Lower Cardiovascular Events in Addition to Standard Therapy in Subjects with Acute Coronary Syndrome–Thrombolysis in Myocardial Infarction 51
  Year:	2011, 2013

  Summary Slide(s):	ATLAS ACS 2-TIMI 51 Summary Slide (Update)
  Clinical Image:	ATLAS ACS 2-TIMI 51 Presentation Slides
  Clinical Image:	ATLAS ACS 2-TIMI 51 Discussant Slides
  Clinical Trial:	Anti-Xa Therapy to Lower cardiovascular events in addition to Aspirin with or without thienopyridine therapy in Subjects with Acute Coronary Syndrome–Thrombolysis In Myocardial Infarction 46
  Clinical Trial:	Apixaban for Prevention of Acute Ischemic and Safety Events
  Clinical Trial:	Apixaban for Prevention of Acute Ischemic Events 2
  Clinical Trial:	Regulation of Coagulation in Orthopedic Surgery to Prevent Deep Venous Thrombosis and Pulmonary Embolism 1
  Clinical Trial:	Regulation of Coagulation in Orthopedic Surgery to Prevent Deep Venous Thrombosis and Pulmonary Embolism 2
  Clinical Trial:	Regulation of Coagulation in Orthopedic Surgery to Prevent Deep Venous Thrombosis and Pulmonary Embolism 3
  Clinical Trial:	Regulation of Coagulation in Orthopaedic Surgery to Prevent Deep Vein Thrombosis and Pulmonary Embolism 4
  Clinical Trial:	Safety, Tolerability, and Efficacy of Darexaban (YM150) in Patients With Acute Coronary Syndrome
  Journal Scan:	Rivaroxaban in Patients With a Recent Acute Coronary Syndrome
  Journal Scan:	Reduction of Stent Thrombosis in Patients With Acute Coronary Syndrome Treated With Rivaroxaban in ATLAS ACS 2–TIMI 51

• TACT
  Title:	The Trial to Assess Chelation Therapy
  Year:	2013

  :	TACT: Disodium EDTA Chelation May Benefit Patients Post-MI
  Cardiosource Video News:	TACT Trial Press Conference
  Cardiosource Video News:	TACT QofL Press Conference
  Cardiosource Video News:	Hallway Buzz: TACT / Ohman Perspective
  Journal Scan:	Effect of Disodium EDTA Chelation Regimen on Cardiovascular Events in Patients With Previous Myocardial Infarction: The TACT Randomized Trial

• RESPECT
  Title:	Randomized Evaluation of Recurrent Stroke Comparing PFO Closure to Established Current Standard of Care Treatment
  Year:	2013

  Summary Slide(s):	RESPECT Summary Slide
  Cardiosource Video News:	PCI Trends and PFO Closure
  Clinical Image:	RESPECT Presentation Slides (TCT 2012)
  Clinical Trial:	Evaluation of the STARFlex Septal Closure System in Patients With a Stroke and/or Transient Ischemic Attack Due to Presumed Paradoxical Embolism Through a Patent Foramen Ovale
  Clinical Trial:	Migraine Intervention With STARFlex Technology
  Clinical Trial:	Percutaneous Closure of Patent Foramen Ovale Versus Medical Treatment in Patients With Cryptogenic Embolism
  :	RESPECT Trial Suggests Closure With AMPLATZER PFO Occluder May Reduce Stroke Risks

• PC
  Title:	Percutaneous Closure of Patent Foramen Ovale Versus Medical Treatment in Patients With Cryptogenic Embolism
  Year:	2013

  Summary Slide(s):	PC Summary Slide
  Cardiosource Video News:	PCI Trends and PFO Closure
  Clinical Image:	The PC Trial Presentation Slides (TCT 2012)
  Clinical Trial:	Evaluation of the STARFlex Septal Closure System in Patients With a Stroke and/or Transient Ischemic Attack Due to Presumed Paradoxical Embolism Through a Patent Foramen Ovale
  Clinical Trial:	Migraine Intervention With STARFlex Technology
  Clinical Trial:	Randomized Evaluation of Recurrent Stroke Comparing PFO Closure to Established Current Standard of Care Treatment
  :	The PC Trial: PFO Closure Not Statistically Superior to Medical Therapy for Stroke Prevention

• SYNTAX
  Title:	Synergy Between Percutaneous Coronary Intervention With TAXUS and Cardiac Surgery
  Year:	2013, 2011, 2009

  Summary Slide(s):	SYNTAX Trial
  Clinical Trial:	Synergy Between Percutaneous Coronary Intervention With TAXUS and Cardiac Surgery Registry
  Clinical Trial:	Bypass Angioplasty Revascularization Investigation
  Clinical Trial:	Arterial Revascularization Therapies Study
  Clinical Trial:	A Randomized Comparison of Sirolimus- Versus Paclitaxel-Eluting Stent Implantation in Patients With Diabetes Mellitus
  Clinical Trial:	Sirolimus-Eluting Stent Compared With Paclitaxel-Eluting Stent for Coronary Revascularization
  Clinical Trial:	Paclitaxel-Eluting Stent Versus Sirolimus-Eluting Stent for the Prevention of Restenosis in Diabetic Patients With Coronary Artery Disease
  Clinical Trial:	Coronary Artery Revascularization in Diabetes Trial
  Clinical Trial:	Randomized Comparison of Minimally Invasive Direct Coronary Artery Bypass Surgery Versus Sirolimus-Eluting Stenting in Isolated Proximal Left Anterior Descending Coronary Artery Stenosis

• PEITHO
  Title:	Pulmonary Embolism Thrombolysis Study
  Year:

  Summary Slide(s):	PEITHO Summary Slide
  Clinical Image:	PEITHO Presentation Slides (ACC.13)
  Cardiosource Video News:	LBCT - PEITHO

• ASTRONAUT
  Title:	Aliskiren Trial on Acute Heart Failure Outcomes
  Year:	2013

  Summary Slide(s):	ASTRONAUT Summary Slide
  Clinical Image:	ASTRONAUT Presentation Slides (ACC.13)
  Journal Scan:	Effect of Aliskiren on Postdischarge Mortality and Heart Failure Readmissions Among Patients Hospitalized for Heart Failure: The ASTRONAUT Randomized Trial

• DIG
  Title:	Digoxin Investigation Group
  Year:	2013, 1997

  Summary Slide(s):	DIG Summary Slide
  Clinical Image:	DIG Presentation Slides (ACC.13)
  Clinical Trial:	Enalapril versus Digoxin in Patients with Congestive Heart failure: A Multicenter Study (Canadian Enalapril versus Digoxin Study Group)
  Clinical Trial:	Randomized Study Assessing the Effect of Digoxin Withdrawal in Patients with Mild to Moderate Chronic Congestive Heart failure: Results of the PROVED
  Clinical Trial:	Withdrawal of Digoxin from Patients with Chronic Heart failure Treated with Angiotensin-Converting Enzyme Inhibitors

• PREVAIL
  Title:	Prospective Randomized EVAuation of the WATCHMAN LAA Closure Device In Patients with Atrial Fibrillation vs. Long-Term Warfarin Therapy
  Year:

  Summary Slide(s):	PREVAIL Summary Slide
  Clinical Image:	PREVAIL Presentation Slides
  Clinical Trial:	WATCHMAN Left Atrial Appendage System for Embolic Protection in Patients With Atrial Fibrillation

• CORONARY
  Title:	CABG Off or On Pump Revascularization Study
  Year:	2012

  Summary Slide(s):	CORONARY Summary Slide
  Clinical Image:	CORONARY Presentation Slides (ACC.13)
  Journal Scan:	Effects of Off-Pump and On-Pump Coronary-Artery Bypass Grafting at 1 Year
  Clinical Image:	CORONARY Presentation Slides
  Journal Scan:	Off-Pump or On-Pump Coronary-Artery Bypass Grafting at 30 Days
  Cardiosource Video News:	Monday Highlights Pt I: CORONARY and ACRIN PA 4500
  Cardiosource Video News:	CORONARY Study
  Clinical Trial:	Randomized On/Off Bypass trial
  Clinical Trial:	German Off-Pump Coronary Artery Bypass Grafting in Elderly Patients

• GOPCABE
  Title:	German Off-Pump Coronary Artery Bypass Grafting in Elderly Patients
  Year:	2013

  Clinical Image:	GOPCABE Presentation Slides (ACC.13)
  Journal Scan:	Off-Pump Versus On-Pump Coronary-Artery Bypass Grafting in Elderly Patients
  Clinical Trial:	Randomized On/Off Bypass trial
  Clinical Trial:	CABG Off or On Pump Revascularization Study

• MASS COMM
  Title:	Randomized Trial to Compare Percutaneous Coronary Intervention Between Massachusetts Hospitals With Cardiac Surgery On-Site and Community Hospitals Without Cardiac Surgery On-Site
  Year:	2013

  Clinical Image:	MASS COMM Presentation Slides (ACC.13)
  Journal Scan:	Nonemergency PCI at Hospitals With or Without On-Site Cardiac Surgery
  Clinical Trial:	Atlantic Cardiovascular Patient Outcomes Research Team−E Trial
  Cardiosource Video News:	LBCT - MASS COMM

• PARTNER Cohort A: TAVR vs. Surgical AVR
  Title:	Placement of Aortic Transcatheter Valves (Cohort A): TAVR vs. Surgical AVR
  Year:	2012, 2011

  Summary Slide(s):	PARTNER Cohort A Summary Slide
  Clinical Image:	PARTNER Trial Presentation Slides (ACC.13)
  Clinical Image:	PARTNER Cohort A Update Presentation Slides
  Clinical Image:	PARTNER Cohort A Presentation Slides
  Clinical Trial:	Placement of Aortic Transcatheter Valves (Cohort B): Transfemoral TAVR vs. Medical Management
  Cardiosource Video News:	Myocardial Injury and Outcomes of TAVR
  Clinical Trial:	A Prospective, Randomized Trial of Transapical Transcatheter Aortic Valve Implantation vs. Surgical Aortic Valve Replacement in Operable Elderly Patients With Aortic Stenosis
  Journal Scan:	Two-Year Outcomes After Transcatheter or Surgical Aortic-Valve Replacement
  Cardiosource Video News:	Monday Highlights Pt II: EINSTEIN, PARTNER Trials
  Cardiosource Video News:	PARTNER Three Year Outcomes

• ACRIN PA 4005
  Title:	CT Angiography for Safe Discharge of Patients With Possible Acute Coronary Syndromes
  Year:	2013, 2012

  Summary Slide(s):	ACRIN PA 4005 Summary Slide
  Clinical Image:	ACRIN PA 4005 Presentation Slides (ACC.13)
  Journal Scan:	CT Angiography for Safe Discharge of Patients With Possible Acute Coronary Syndromes
  Clinical Image:	ACRIN PA 4005 Presentation Slides
  Cardiosource Video News:	Monday Highlights Pt I: CORONARY and ACRIN PA 4500
  Cardiosource Video News:	ACRIN PA 4500 Study

• DES-LATE
  Title:	Duration of Dual Antiplatelet Therapy After Implantation of Drug-Eluting Stents
  Year:	2010

  Summary Slide(s):	DES-LATE Trial
  Clinical Trial:	Comparison of the Efficacy and Safety of Zotarolimus-Eluting Stent with Sirolimus-Eluting and PacliTaxel-Eluting Stent for Coronary Lesions
  Clinical Image:	DES LATE Presentation Slides (ACC.13)

• RED-HF
  Title:	Reduction of Events by Darbepoetin Alfa in Heart Failure
  Year:	2013

  Clinical Image:	RED-HF Presentation Slides (ACC.13)
  Cardiosource Video News:	RED-HF Trial

• TERISA
  Title:	Type 2 Diabetes Evaluation of Ranolazine in Subjects With Chronic Stable Angina
  Year:	2013

  Clinical Trial:	Combination Assessment of Ranolazine in Stable Angina
  Clinical Trial:	Fractional Flow Reserve Versus Angiography for Multivessel Evaluation 2
  Clinical Trial:	Clinical Outcomes Utilizing Revascularization and Aggressive Drug Evaluation
  Clinical Trial:	Metabolic Efficiency With Ranolazine for Less Ischemia in NSTE-ACS
  Clinical Image:	TERISA Presentation Slides (ACC.13)
  Journal Scan:	Evaluation of Ranolazine in Patients With Type 2 Diabetes Mellitus and Chronic Stable Angina: Results From the TERISA Randomized Clinical Trial
  Cardiosource Video News:	Terisa and SELECT-ACS Trials

• SELECT-ACS
  Title:	Effects of the P-Selectin Antagonist Inclacumab on Myocardial Damage After Percutaneous Coronary Intervention for Non-ST-Elevation Myocardial Infarction
  Year:	2013

  Summary Slide(s):	SELECT-ACS Summary Slide
  Clinical Image:	SELECT-ACS Presentation Slides (ACC.13)
  Cardiosource Video News:	Terisa and SELECT-ACS Trials

• REMINDER
  Title:	Safety and Efficacy of Early Treatment With Eplerenone in Patients With Acute Myocardial Infarction
  Year:

  Summary Slide(s):	REMINDER Summary Slide
  Clinical Image:	REMINDER Presentation Slides (ACC.13)